A preeminent business leader of the country, Mir Nasir Hossain has a diverse range of business interests including Construction, Real Estate, Telecom, ICT, Software Development, Ceramic Tiles Manufacturing, Textile, Liquefied Petroleum Gas (LPG), Banking and Insurance. He excelled as a student and achieved his post-graduation in accounting from the University of Dhaka with distinction. A founding director of EBL, he joined the Board in 1993.

Mir Telecom Limited, a business concern under his dynamic leadership, won the National Export Trophy Gold Category in 2012-2013, 2013-2014, 2016-2017, 2017-2018, 2018-2019, 2019-2020 in service sector and received National Productivity and Excellence Award 2021 for Mir Akhter Hossain Limited. He received the export trophy award from the Honorable Prime Minister of Bangladesh and was declared a CIP (Commercially Important Person) by the Ministry of Industries for 2012, 2013, 2017 and CIP Export 2014, 2015 & 2018 from the Ministry of Commerce for his significant contributions to the industrial growth of the country.

He led the Federation of Bangladesh Chambers of Commerce and Industry (FBCCI), the apex trade organization of the country, as its President from 2005 to 2007, and served the organization prudently with commitment and dedication. He held many important positions in various regional business and trade bodies including Senior Vice President of SAARC Chamber of Commerce and Industry (SAARC CCI) and Vice President of Confederation of Asia Pacific Chambers of Commerce and Industry (CACCI). Currently, he is the President of Faridpur Diabetic Association and Chairman of the Governing Body of Faridpur Diabetic Association Medical College. He is the Chairman of Mir Securities Limited.

He is the Chairman of both Executive Committee (EC) and Risk Management Committee (RMC) of the Board of EBL.

He is actively engaged in various social works, most notably Bangladesh Red Crescent Society as a life time member.